Sol de America continued their perfect start to the Paraguayan Apertura with a 2-0 victory over previously unbeaten Rubio Nu.
The league leaders took the lead with just four minutes on the clock when Diego Ciz's far-post cross was converted by Jose Ortigoza.
And it was 2-0 before half time as Gilberto Velazquez was unable to control a corner properly and ended up diverting the ball into his own net.
Elsewhere, Independiente FBC secured their first point of the season as they came from behind to draw 1-1 at 2011 Clausura champions Olimpia.
Pablo Zeballos gave the hosts the lead in the 10th minute but Independiente equalised through Luis Mino and held on for a draw.
Nacional Asuncion conceded just 34 seconds into their match with Guarani before fighting back to emerge as 3-1 winners.
Fabio Escobar scored the early goal to get the hosts off to a perfect start but they then saw goalkeeper Pablo Aurrecochea dismissed after 22 minutes for a foul in the area.
Herminio Miranda stepped up to equalise from the spot and second-half goals from David Mendoza and German Cano sealed victory.
Roberto Nanni scored the only goal of the game as Cerro Porteno narrowly overcame newly-promoted Cerro Porteno PF in Asuncion.
The hosts got the breakthrough after 15 minutes on a day that also saw police arrest 50 Cerro fans and seize a firearm during a raid near the stadium.
Sportivo Luqueno and Deportivo Carapegua drew 1-1, with Claudio Vargas giving Luqueno the lead early in the second half and Eduardo Echeverria replying for the visitors.
On Monday evening, Miguel Samudio scored a late equaliser to rescue a point for Libertad at Tacuary, who took the lead early in the second half through Jorge Ortega.